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dose-treatment: Tramal (Tramadol HCl), 50 mg capsules, was obtained from ultram Mina- Pharm, Egypt .
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[12], the ultram LD50 values of oral administration were estimated to be around 300–350 mg/kg body weight for (rat and mouse) . The therapeutic dose (40 mg/kg body weight) of this drug for rat ultram was calculated according to Paget and Barnes [13] .
The chosen dose was nearly comparable to the human effective therapeutic ultram dose (ETD) .
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