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Based tramadol withdrawal abdominal pain tramadol classification of drug tramadol high dosage erowid on a population PK analysis of Phase I studies in healthy subjects, concentrations of tramadol were approximately 20% higher in « poor metabolizers » versus « extensive metabolizers », while M1 concentrations were 40% lower .
Concomitant therapy with inhibitors of CYP2D6 such as fluoxetine, paroxetine and tramadol quinidine could result in significant drug interactions .
In tramadol tablets in hindi tramadol overdose canine tramadol withdrawal muscle cramps tramadol vitro drug interaction studies in human liver microsomes indicate that inhibitors of CYP2D6 such as fluoxetine and its metabolite norfluoxetine, amitriptyline and quinidine inhibit the metabolism of tramadol to various degrees, suggesting that concomitant administration of these compounds could result in increases in tramadol concentrations and decreased concentrations of M1 .
The full pharmacological impact of these alterations in terms of either efficacy or safety tramadol tylenol dosage tramadol hcl classification tramadol overnight tramadol overdose death is unknown .
Concomitant use of SEROTONIN reuptake tramadol controlled narcotic tramadol 50mg vs codeine tramadol markings tramadol 300 mg er high INHIBITORS and MAO INHIBITORS may enhance the risk of adverse events, including seizure (see WARNINGS) and serotonin syndrome .
Tramadol is eliminated primarily through metabolism by the liver and tramadol and valium overdose tramadol pills 319 tramadol a schedule 4 drug tramadol dosage for gout the metabolites are eliminated primarily by the kidneys .

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