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    Fetal malformations and death have been reported in mice following parenteral administration of d-amphetamine doses of 50 mg/kg/day (approximately 10 times the MRHD for adolescents on a mg/m2 basis) or amphetamine greater to pregnant animals .
    Administration of these amphetamine doses was also associated with severe maternal toxicity .
    A study was conducted in which pregnant rats received daily oral doses of amphetamine (d- to l- enantiomer ratio of 3:1, the same as in ADDERALL XR) of 2, amphetamine 6, and 10 mg/kg from gestation day 6 to lactation day 20 .
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