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Other effects included increased pre-implantation loss (noeffect dose 25 mg/kg), eszopiclone abnormal estrus cycles (no-effect dose 25 mg/kg), and decreases in sperm number and motility and increases in morphologically abnormal sperm (no-effect dose 5 mg/kg) .
Pregnancy Category C Eszopiclone administered by oral gavage to pregnant rats and rabbits during the period of organogenesis showed no evidence of teratogenicity up to the highest doses tested (250 and 16 mg/kg/day in rats and rabbits, respectively; these doses are 800 and 100 times, respectively, the maximum eszopiclone recommended human dose [MRHD] on a mg/m2 basis) .
In eszopiclone the rat, slight reductions in 21476 FDA approved labeling text 1 . 5 eszopiclone mg/kg/day (200 times the MRHD on a mg/m2 basis) . 08 fetal weight and evidence of developmental delay were seen at maternally eszopiclone cut in half imovane quand le prendre eszopiclone o que é zopiclone with diazepam toxic doses of 125 and 150 mg/kg/day, but not at 62 .
Eszopiclone was also administered by oral gavage to pregnant rats throughout the pregnancy and lactation periods at doses of up eszopiclone to 180 mg/kg/day .
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Eszopiclone had no effects on other behavioral measures eszopiclone or reproductive function in the offspring .
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