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Similar drugs such as administration of opioid antagonist naloxone to female tramadol rats was found to cause reproductive failure [15] .
Clonidine and yohimbine drugs were found to decrease estradiol and increase the bulk of tramadol cysts and corpus lutea [16] .
Thienorphine was a partial opioid agonist with long-lasting antinociceptive was found to induce a concentration-dependent decrease in the frequency and amplitude of the contraction on the isolated oestrus and pregnant tramadol uterine strips [17] .
tramadol 100 mg overdose tramadol 50 mg uses tramadol 50mg side effects nhs tramadol schedule Estradiol was found to increase cell density and stimulate of cell proliferation . However, the opioid-induced inhibition tramadol of uterine cell proliferation which was mediated mainly by the mu opiate receptor [19] . Tramadol caused a concentration-dependent inhibition of potassium chloride -induced myometrial tramadol contractility [18] .
In addition, tramadol-treatment caused focal disorganization of seminiferous tubules tramadol compared to norco opiate withdrawal kidneys tramadol withdrawal months later tramadol high with marked depletion of the spermatogenic cell populations .
Exfoliation of the damaged spermatocytes and spermatids were detected within the tubular lumina of many of the seminiferous tramadol tubules .
The intertubular connective tissue become tramadol hyalinized and showed comparative reduction of interstitial cells .
Following flowcytometric analysis , tramadol there was a marked increase of apoptic spermatogenic cells .
The observed findings supported the recent work carried out following tramadol-treatment by tramadol Ahmed and Kurkar [14] and Abdellatief et al .

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