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Node Positive – Individual Studies: Two studies (Hubay and NSABP B-09) demonstrated an improved disease-free survival following radical or modified radical mastectomy in postmenopausal women or women tamoxifen 50 years of age or older with surgically curable breast cancer with positive axillary nodes when NOLVADEX was added to adjuvant cytotoxic chemotherapy .
In the Hubay study, NOLVADEX buy nolvadex liquid nolvadex estrogen rebound buy nolvadex online cheap nolvadex and clomid post was added to « low-dose » CMF (cyclophosphamide, methotrexate and fluorouracil) .
In the NSABP B-09 study, NOLVADEX was added to melphalan [Lphenylalanine tamoxifen mustard (P)] and fluorouracil (F) .
In the Hubay study, patients with a positive (more than tamoxifen 3 fmol) estrogen receptor were more likely to benefit .
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Three prospective studies (ECOG-1178, Toronto, NATO) using NOLVADEX adjuvantly as a single agent tamoxifen demonstrated an improved disease-free survival following total mastectomy and axillary dissection for postmenopausal women with positive axillary nodes compared to placebo/no treatment controls .
tamoxifen The NATO study also demonstrated an overall survival benefit .

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