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Type I 5α-reductase is responsible for approximately one-third of finasteride circulating DHT .
The Type II 5α-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and finasteride hair follicles as well as liver, and is responsible for two-thirds of circulating DHT .
In humans, the mechanism finasteride of action of finasteride is based on its preferential inhibition of the Type II isozyme .
Using native tissues (scalp and prostate), in vitro binding studies examining the potential of finasteride to inhibit either isozyme revealed a 100-fold selectivity for the human Type II 5α-reductase over Type I isozyme (IC50=500 and finasteride 4 . 2 nM for Type I finasteride and II, respectively) .
For both Buy finasteride usa cod,buying finasteride online,cheap finasteride fast shipping Buy finasteride, finasteride isozymes, the inhibition by finasteride is accompanied by reduction of the inhibitor to dihydrofinasteride and adduct formation with NADP+ .
The turnover for the enzyme complex is slow (t1/2 approximately 30 finasteride days for the Type II enzyme complex and 14 days for the Type I complex) .
Inhibition of Type II 5α-reductase blocks the peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT In men with male finasteride pattern hair loss (androgenetic alopecia), the balding scalp contains miniaturized hair follicles and increased amounts of DHT compared with hairy scalp .
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